EBCOG Part 1 Oncology – Day 2 EMQ

a.Lactate dehydrogenase     
b.CA 19-9             
c.CA 72-4           
d.Carcinoembryonic antigen
e.Epithelial tumour antigen
f.Oestriol
g.Alfa feto protein
h.Homeobox protein
i.Human chorionic gonadotropin
j.Human epididymic protein
k.Inhibin
l.Oestradiol
m.Beta HCG
n.CA 125
o.inhibin B
p.inhibin A

for each of the following scenarios choose the most appropriate tumour marker.Each option may be chosen once ,more than once or not at all.

1.Compound produced by both Sertoli cells of the testis & granulosa cell tumours of the ovary,belonging to the transforming growth factor-β (TGF-β)-superfamily

                                  
                                            
                                           

2.A steroid that is almost undetectable in the non pregnant female,but whose levels rise >1000 fold during pregnancy & choriocarcinoma.

3.A compound that is elevated in women with an ovarian dysgerminoma,also in third trimester of pregnancy.

4.A 55 year old lady presented with postmenopausal bleeding.On investigation she was foind to have a ovarian mass .She underwent surgery & the ovarian mass was found to be a granulosa cell tumour.Which tumour marker will be raised ?

5.Women with epithelial ovarian cancer who are on follow up after definitive chemoradiotherapy.Which tumour marker is used to look for recurrence?