Biochemistry
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Question 1 of 52
1. Question
1. Hormone which act via cGMP as second messenger is-
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Question 2 of 52
2. Question
2. Biochemical functions of choline are all except-
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Question 3 of 52
3. Question
3. Biochemical functions of phosphatidyl Inositol are all except-
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Question 4 of 52
4. Question
4. Pyridoxal phosphate acts as co-enzyme for all the enzymes except-
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Question 5 of 52
5. Question
5. 75 years old farmer visited general practitioner with weakness, diarrhoea, decreased vision and purulent discharge from eyes. On examination, there were subcutaneous haemorrhage in the arms and legs. Eyes showed marked inflammation and dilatation of conjunctiva vessels and margins of eyelid, fissure at the angle of the mouth, tongue was sore and swollen. Deep tendon reflexes were diminished. Which vitamin deficiency causes changes in the eye?
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Question 6 of 52
6. Question
6. Coenzymes are involved in transferring the groups from one substrate to another substrate. Which of the subset is a mismatch?
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Question 7 of 52
7. Question
7. Zymogen which is dependent on the post translation modification by the vitamin K is-
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Question 8 of 52
8. Question
8. Mother brought 2 months old baby for history of red patches under skin in the anterior region of both thighs and knee. Baby had received oral vitamin K prophylaxis at birth. Neonatal period was normal. Baby was exclusively breastfed. Laboratory investigation showed Hb- 6gm%, PT- 40 secs, normal platelet count, normal fibrinogen level. Vitamin K was administered with complete recovery. Vitamin administration acts as a coenzyme for which of the following post translational reaction?
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Question 9 of 52
9. Question
9. Which is not true regarding the activation of vitamin D?
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Question 10 of 52
10. Question
10. A 50-year old woman presents to her physician complaining of weakness, walking difficulty and peripheral neuritis. A careful history reveals that she is malnourished. She is found to have a severe thiamine deficiency. The function of which of the following enzymes in the citric acid cycle would be most directly affected by the riboflavin deficiency?
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Question 11 of 52
11. Question
11. All of the following are the anaplerotic reactions of Krebs Cycle except-
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Question 12 of 52
12. Question
12. 60-year-old man developed signs of Parkinson’s disease at the age of 47. He presented with mild resting tremors and decreased arm swing while walking. A year later he began taking 500mgof L -DOPA with peripheral decarboxylase inhibitor with excellent response. Which of the following amino acid’s metabolism is defective?
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Question 13 of 52
13. Question
13. All of the compounds are the products of tyrosine metabolism except-
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Question 14 of 52
14. Question
14. Glycine is the simplest, nonessential amino acid helps in formation of various compounds except-
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Question 15 of 52
15. Question
15. Methyl transferase enzyme transfer the methyl group from the S-adenosyl methionine to the acceptor forming methylated products. All of the following are methylated product except-
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Question 16 of 52
16. Question
16. One carbon group is utilized in the synthesis of the following compound except-
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Question 17 of 52
17. Question
17. Identify the wrong statement with respect to metabolic functions of subcellular organelle –
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Question 18 of 52
18. Question
18. Which of the following is not a multi enzyme complex?
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Question 19 of 52
19. Question
19. Which of the following is not a branched chain amino acid?
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Question 20 of 52
20. Question
20. Which of the metabolic statement regarding methionine is false.
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Question 21 of 52
21. Question
21. Which of the following is not an essential amino acid?
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Question 22 of 52
22. Question
22. Which of the following product is not derived from cholesterol?
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Question 23 of 52
23. Question
23. Which of the following is wrong about Thromboxane A2?
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Question 24 of 52
24. Question
24. A 40-year-old man presented to emergency department with one-week history of weakness, fever, nausea, vomiting and a painful left foot with foul smelling pus discharge from ulcer on the sole. Past history of type 2 diabetes > 6 years, dyslipidemia and hypertension. He was on gliclazide and metformin since diagnosis and mixtard was started for 6 months because of poor glycaemic control. He stopped injecting insulin for 1 week ago – poor appetite precipitated hypoglycaemia. Temperature 38.90C, BP 96/60 mmHg, Pulse 140 beats/minute, respiratory rate 33 /minute, deep sighing breathing, drowsy but arousable. Tongue coated, dry mucosa and decrease skin turgor. All of the metabolic derangements have happened in this patient except-
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Question 25 of 52
25. Question
25. Which one of the following statements concerning gluconeogenesis is not correct?
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Question 26 of 52
26. Question
26. A young man presents with history of bloating and diarrhoea and signs of dehydration after attending birthday party, indulging on pastries and ice creams. Patient is afebrile. The patient has experienced similar episodes following ingestion of a significant number of dairy products. This clinical picture is most probably due to a deficiency in the activity of:
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Question 27 of 52
27. Question
27. Which of the following statement is wrong about the absorption of carbohydrate.
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Question 28 of 52
28. Question
28. Which of the following is wrong about the Rapaport-Leubering cycle?
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Question 29 of 52
29. Question
29. In which of the following cells, anerobic metabolism does not occur?
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Question 30 of 52
30. Question
30. Maternally inherited mitochondrial disorders are all of the following except-
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Question 31 of 52
31. Question
31. Compounds which are formed from pyruvate are all except-
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Question 32 of 52
32. Question
32. An 18-year-old boy was admitted to hospital with yellowish discoloration of sclerae, fatigue, and paleness, splenomegaly. His history revealed that he had suffered severe anemia since the neonatal period. His parents were married within same family. Laboratory investigation reveals: Hb-6gm%, Peripheral smear showing marked anisopoikilocytosis, polychromia, reticulocyte count-30%, total bilirubin – 15mg/dL, conjugated bilirubin- 5mg/dL, normal haemoglobin electrophoresis, Direct coomb’s test negative. Patient suspected of chronic nonsperocytic hemolytic anemia. Enzymatic evaluation showed Pyruvate kinase – 9.7 (ref value: 11.9 – 16 U/g Hb) and rest of the red blood cell enzyme assays were normal. Which of the following statement is wrong?
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Question 33 of 52
33. Question
33. Von Gierke’s disease involves a deficiency of which of the following enzymes-
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Question 34 of 52
34. Question
34. 30-year-old female presents to GP with history of weakness, muscle cramps and observed reddish discoloration of urine after playing a match of shuttle badminton. She feels more as loner. Her friends find her lazy and reluctant to play. She used to feel fatigued. Which of the following enzyme deficiency would lead to this kind of presentation?
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Question 35 of 52
35. Question
35. Key glycolytic enzymes are all except-
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Question 36 of 52
36. Question
36. Hereditary fructose intolerance is carbohydrate metabolic error because of the deficiency of enzyme which catalyse one of the following reaction-
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Question 37 of 52
37. Question
37. One-week old neonate presented to the hospital with mild jaundice, poor feeding, vomiting, abdominal distension. Laboratory investigation revealed abnormal liver function test and positive for urine reducing substance. On ophthalmoscopy evaluation showed cataract in both eyes. The development of the cataract is because of elevated levels of-
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Question 38 of 52
38. Question
38. During the well-fed state insulin activates all of the following enzymes except-
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Question 39 of 52
39. Question
39. Reduced coenzyme product derived from the HMP pathway are involved in all except-
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Question 40 of 52
40. Question
40. Uncouplers dissipate the H+ gradient across the inner mitochondrial membrane and the energy is released as heat instead of ATP production. All of the following are the physiological uncouplers except-
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Question 41 of 52
41. Question
41. Iron deficiency anemia 12 years old girl presented with 3-month history of chest discomfort on exertion, palpitation, light headedness and generalised fatigability. There is no history of loss of consciousness, significant shortness of breath. There is history of pain during defecation and constipation. She had no history of weight loss or anorexia and. During the follow up visit, patient was reluctant to reveal unusual the eating habit. Patient disclosed craving to eat chalk from past one year. Laboratory investigation: Hb-6gm%(12-16gm%), MCV-70fl(79-90fl); MCHC-300g/Lt(32-36g/dL); Reticulocyte- 15%, Peripheral smear- microcytic hypochromic anemia.
Which of the enzyme is affected in ATP production?CorrectIncorrect -
Question 42 of 52
42. Question
42. Which of the mineral is required for the oxidative phosphorylation?
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Question 43 of 52
43. Question
43. All of the following are antioxidant vitamin except?
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Question 44 of 52
44. Question
44. Which of the following mineral has antioxidant role?
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Question 45 of 52
45. Question
45. All of the following are Zinc dependent enzymes except-
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Question 46 of 52
46. Question
46. 3-year-old boy brought to the hospital for the aggressive behaviour with lip chewing, tongue and finger biting. Laboratory report of serum uric acid is 20mg/dL (3.4-7mg/dL).
Which of the following enzyme deficiency leads to presentation of the clinical symptom?CorrectIncorrect -
Question 47 of 52
47. Question
47. Micronutrients required for the heme synthesis are all except-
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Question 48 of 52
48. Question
48. 30-year-old man brought his routine blood reports to GP with elevated levels of alkaline phosphate. Lab reports, Serum ALP-400IU/L( reference value<130 IU/L), AST- 20 IU/L,AST- 16 IU/L, Total bilirubin- 1mg/dl. Patient complains of vague pain in his hip.
All of the following markers have isoenzymes except-CorrectIncorrect -
Question 49 of 52
49. Question
49. 18 months old female child brought to emergency department with 12-15 episodes of persistent vomiting and drowsiness, mild hepatomegaly. There is history of sudden death of previous child. Plasma glucose was 18mg/dL, Plasma ammonia- 70µmol/L ((6-50 µmol/L) Arterial blood pH-7.25, pCO2-30mmHg, bicarbonate-15mmol/L negative for urine ketones. Acyl carnitine profile revealed free carnitine (40 (15.5–46.7)), hexanoylcarnitine -1.02 (0–0.15), octanoylcarnitine -7.8 (0–0.27), decenoylcarnitine-1.22 (0–0.25), decanoylcarnitine-0.67 (0–0.32). Urinary organic acids showed moderately elevated hexanoylglycine, mildly increased suberylglycine and phenylpropionylglycine. No ketones and carboxylic acids.
Name the deficient enzyme in this child.CorrectIncorrect -
Question 50 of 52
50. Question
50. Which of the following is not a positive acute phase protein?
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Question 51 of 52
51. Question
51. All of the following are the phospholipids except-
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Question 52 of 52
52. Question
52. Heme containing proteins are all except-
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