EBCOG Part 1-Drug therapy in obstetrics and gynaecology

1. With regards to mifepristone:

A It is a progesterone receptor agonist

B It is an 11b-dimethyl-amino-phenyl derivative

C It has a high affinity for progesterone receptors

D It has a high affinity for glucocorticoid receptors

E It blocks the progesterone receptors in the myometrium and cervix

2. Mifepristone:

A Is absolutely contraindicated in women with adrenal insufficiency

B Is absolutely contraindicated in women with mild asthma

C Is absolutely contraindicated in women on anticoagulant therapy

D Is absolutely contraindicated in women with hypertension

E Is absolutely contraindicated in women smokers <25 years age

3.With regards to antihypertensive drug use during pregnancy:

A Methyldopa is an a1-agonist

B Methyldopa can cause systemic lupus erythematosus (SLE) like symptoms

C Methyldopa may cause a positive Coomb’s test

D Methyldopa may cause a raised serum alanine aminotransferase

E Methyldopa is contraindicated in women with intrauterine fetal growth restriction (IUGR)

4.With regards to antihypertensive drugs:

A Sodium nitroprusside can be safely used during all trimesters of pregnancy

B Atenolol can be safely used to treat pre-eclampsia during pregnancy

C Diazoxide can be safely used during pregnancy

D Angiotensin converting enzyme (ACE) inhibitors can be safely used during

pregnancy

E Nifedipine can be safely used during pregnancy

5.With regards to antihypertensive treatment during pregnancy:

A Labetalol should be used with caution in women with asthma

B Labetalol has a positive effect on fetal lung maturation in women with severe hypertension who are distant from term

C Intravenous labetalol, when used for treating severe hypertension, causes more reflex tachycardia than hydralazine

D Intravenous hydralazine causes controlled decrease in blood pressure when administered for treatment of severe hypertension

E Intravenous nitroglycerine in high doses may result in methemoglobinemia

6.The following abnormalities and drugs are correctly matched:

A Neural tube defects – sodium valproate

B Ebstein’s anomaly – lithium

C Orofacial defects – carbamazepine

D Limb defects – thalidomide

E Vaginal adenosis – diethylstilboestrol

7.Tranexamic acid:

A Is an antifibrinolytic agent

B Is used as a third line drug for the treatment of menorrhagia

C Increases endometrial tissue plasminogen activator activity

D Reduces menstrual blood loss by 90%

E Can cause dysmenorrhoea

8.With regards to heparin:

A Unfractionated heparin crosses the placenta

B Low molecular weight heparin (LMWH) increases the risk of fetalhaemorrhage

C Thrombocytopenia is more common with LMWH compared to unfractionated heparin

D Unfractionated heparin can cause symptomatic osteoporosis

E LMWH has a better side effect profile compared to unfractionated heparin

9.With regards to warfarin and pregnancy:

A It crosses the placenta

B It is not a teratogen

C Epidural anaesthesia can be used if mother is on warfarin

D Spinal anaesthesia can be used if mother is on warfarin

E Its use should be avoided after 36 weeks of gestation

10.With regards to Dextran 70:

A It can be safely used in pregnancy

B It can cause an anaphylactoid reaction in the mother

C It can cause uterine hypotonus

D It can cause fetal distress

E It can cause fetal death