EBCOG PART 1 – GYNAECOLOGICAL ONCOLOGY

1. With regards to familial breast/ovarian cancer:

A It is inherited as an autosomal dominant trait

B It can be due to mutations in the BRCA1 gene on the short arm of chromosome 17

C The lifetime risk of breast cancer is 99% if a woman carries the BRCA1  mutation

D The lifetime risk of ovarian cancer is 10% if a woman carries the BRCA1  mutation

E Men with the mutant gene usually develop cancer

2. With regards to the staging of endometrial cancer:

A Stage Ia: Endometrial adenocarcinoma confined to the uterus but involving less than half of the myometrium

B Stage II: Endometrial adenocarcinoma involving more than half of the myometrium and cervical stroma

C Stage IVa: Endometrial adenocarcinoma invading bladder mucosa

D Stage IVb: Endometrial adenocarcinoma involving inguinal lymph nodes

E Stage IIIC2: Endometrial adenocarcinoma involving more than half of the myometrium and involvement of pelvic nodes

3. The following are true with regards to epithelial ovarian cancer:

A Peak incidence is at 50–70 years

B Late presentation

C Vague symptoms

D Most are advanced stage at diagnosis

E Overall 5-year survival is around 30%

4. The following are correctly matched:

A Dermoid cyst – Immature teratoma

B Germ cell tumour – Endodermal sinus tumour

C Diethylstilboestrol – Vaginal squamous cell carcinoma in offspring

D Aniline dyes – Uterine carcinoma

E HPV 18 – Adenocarcinoma of cervix

5. The following tumour markers are correctly matched:

A Seminomas – alpha fetoprotein (AFP)

B Endodermal sinus tumour – AFP

C Choriocarcinoma – beta human chorionic gonadotrophin (hCG)

D Granulose cell tumour – inhibin

E Dysgerminoma – lactate dehydrogenase

6. Serum testosterone levels are increased in the following conditions:

A Late onset congenital adrenal hyperplasia (CAH)

B Polycystic ovary syndrome

C Granulosa cell tumour

D Brenner tumour

E Theca cell tumour

7. With regards to cervical glandular intraepithelial neoplasia:

A It usually presents with intermenstrual bleeding

B The majority of lesions are within 1 cm adjacent to the squamocolumnar

junction

C It has definite well-defined identified patterns for colposcopic diagnosis

D It is associated with human papilloma virus 18

E It is associated with skip lesions higher up in the endocervical canal

8. Atypical endometrial hyperplasia is associated with:

A Coexistent endometrial carcinoma

B Coexistent ovarian tumour

C Coexistent cervical carcinoma

D Progression to uterine sarcoma

E Abnormal uterine bleeding

9. With regards to premalignant lesions of the genital tract:

A One third of untreated women with cervical intraepithelial neoplasia (CIN) III will progress to cancer in 5 years

B CIN I progresses to CIN III or worse in 26% of women within 2 years

C Glandular lesions of the cervix can coexist with squamous lesions

D Glandular abnormality on cervical smear may be associated with fallopian tube cancer

E Glandular abnormality on cervical smear may be associated with endometrial Cancer

10. With regards to treatment methods for cervical intraepithelial neoplasia (CIN):

A Invasive disease needs to be excluded before choosing any destructive methods

B The use of cryotherapy does not require general anaesthesia

C Electrodiathermy requires general anaesthesia

D Knife cone biopsy can be performed under local anaesthesia

E Cold coagulation uses a temperature of –20°C