EBCOG PART 1 – REPRODUCTIVE MEDICINE

1. Ovarian hyperstimulation syndrome (OHSS):

A Is a complication of intrauterine insemination

B Can cause pericardial effusion

C Can lead to renal failure

D Can cause cerebral infarction

E Can cause adult respiratory distress syndrome

2. The following are autosomal recessive conditions:

A Albinism

B Cystic fibrosis

C Congenital adrenal hyperplasia

D Galactosaemia

E Gaucher disease

3. With regards to autosomal recessive inheritance:

A If both parents are carriers, there is a 1 in 4 chance that the mutant gene will be transmitted to the child

B It is always expressed in heterozygous state

C Men and women have an equal chance of being affected

D It is more likely that affected individuals have heterozygous parents

E It is more common in children with parents of consanguineous marriage

4. The following are X-linked or sex-linked recessive disorders:

A Sickle cell disease

B Vitamin D resistant rickets

C Wilson disease

D Duchenne muscular dystrophy

E Hunter syndrome

5. The following are X-linked dominant conditions:

A Red/green colour blindness

B Turner syndrome

C Huntington disease

D Hairy ears

E Haemophilia

6. The following are autosomal dominant inherited conditions:

A Phenylketonuria

B a1 antitrypsin deficiency

C Porphyria variegata

D Sickle cell disease

E Cri du chat syndrome

7. A semen sample is said to be normal if:

A Volume <1 mL

B Motility > 50%

C Sperm concentration 5 million/mL

D Liquefaction time of >120 minutes

E Total sperm number of > 40 million per ejaculate

8. With regards to luteinising hormone (LH) and follicle-stimulating hormone (FSH):

A LH promotes formation of androstenedione from cholesterol (in theca interna

cells) which in turn is transported to granulosa cells to form oestradiol

B LH peaks 4 hours before ovulation

C LH surge occurs 4 days before ovulation

D FSH and LH secretion peak to the highest level during the luteal phase

E LH is released in pulsatile manner during proliferative phase

9. With regards to Turner syndrome:

A Women always present with secondary amenorrhoea

B Women have a karyotype 47XXX

C It is associated with cardiomyopathy

D The external genitalia is usually male

E Women are always infertile

10. Prolactin is increased in the following situations:

A Exercise

B Stress

C Nipple stimulation

D Sleep

E Pregnancy