Endocrinology

1. Hormone secreted from acidophilic cells of pituitary gland

A. LH
B. FSH
C. GH
D. TSH
E. ACTH

2. Which hormone is secreted by posterior pituitary?

A. Oxytocin
B. ACTH
C. FSH
D. LH
E. TSH

3. Secretion of prolactin is inhibited by

A. TRH
B. Dopamine
C. Pregnancy
D. Suckling
E. Dopamine antagonist.

4. Mineralocoticoid is produced from

A. Zona glomerulosa
B. Zona fasciculata
C. Adrenal medulla
D. Ovary
E. Zona reticularis

5. Epinephrine is produced from

A. Adrenal medulla
B. Zona glomerulosa
C. Zona fasciculata
D. Zona reticularis
E. Ovary

6. Site of Angiotensinogen production is

A. Zona glomerulosa
B. Kidney
C. Ovary
D. Liver
E. Adrenal medulla

7. 45 years old female presented with hypertension & purple striae on abdomen & buffalo hump.most likely diagnosis is

A. Addison’s disease
B. Cushing’s syndrome
C. ACTH deficiency
D. Hypothyroidism
E. 21-hydroxylase deficiency

8. Major source ie 95% of testosterone production is

A. Pituitary
B. Testes
C. Ovary
D. Adipose tissue
E. Adrenals

9. At term lactogenesis is stimulated by which hormone

A. Oxytocin
B. HPL
C. Progesterone
D. Prolactin
E. Dopamine

10. Which of the following hormones increases the excretion of calcium in kidney?

A. Insulin
B. Cortisol
C. Calcitonin
D. Parathyroid hormone
E. Antidiuretic hormone

11. LH is structurally related to which other glycoprotein hormones?

A. ADH,oxytocin & FSH
B. FSH,TSH & GH
C. HCG,FSH & TSH
D. HCG,ADH & FSH
E. TSH,GH & HCG

12. Most common cause of Cushing’s syndrome is

A. Pituitary adenoma
B. Adrenal adenoma
C. Adrenal carcinoma
D. Adrenal hyperplasia
E. Iatrogenic steroid administration

13. Regarding Leptin,which of the following is true?

A. Its a toxin causing tissue necrosis in Leprosy.
B. Its a growth factor produced by the pubertal testicle with its main effect on Sertoli cells.
C. Its a hormone produced by fat
D. It is implicated in obesity associated with polycystic ovary syndrome
E. It is a neurotransmitter produced by the hypothalamus leading to immature & reckless behaviour.

14. Which of the following is a recognised cause of loss of body hair?

A. Haemochromatosis
B. Anorexia nervosa
C. Hypothyroidism
D. Sheehans syndrome
E. All of the above.

15. Which metabolic process is due to growth hormone ?

A. Decreased blood glucose concentration
B. Increased glycogen deposition
C. Increased catabolism of protein & amino acids
D. All of the above.
E. None of the above

16. All are features of acromegaly ,except

A. Spenomegaly
B. Intestinal polyposis
C. Palpable peripheral nerves
D. Hypocalciuria
E. Proximal myopathy

17. Chromophobe Adenoma of pituitary commonly causes

A. Addisons disease
B. Hyperthyroidism
C. Hyperprolactinaemia with hypogonadism
D. Sheehans syndrome
E. None of the above

18. Which of the following conditions can cause hyperprolactinaemia?

A. Chronic renal failure
B. LHRH analogue therapy
C. Chlorpropramide therapy
D. Testosterone therapy
E. All of the above.

19. Which of the following clinical conditions doesn’t cause increase in secretion of TSH?

A. Partial removal of thyroid gland
B. When diet is deficient in iodine
C. In infants born without a thyroid gland.
D. In starvation
E. None of the above

20. Which of the following is correct regarding radioactive iodine therapy?

A. It is an effective therapy for thyrotoxicosis due to thyroiditis.
B. It is contraindicated in patients with Graves disease.
C. Breast feeding should be avoided for 8 weeks after therapy.
D. It should be avoided in women of child bearing age.
E. It produces hyperthyroidism in majority of patients treated.

21. Concerning SHBG which of the following is correct?

A. Levels are increased in pregnancy
B. Is the main binding protein for aldosterone
C. Has a lesser affinity than albumin for testosterone
D. Levels decrease during oestrogen therapy
E. Is the main binding protein for progesterone.

22. What is true concerning the adolescent growth spurt?

A. Onset is after 16 years in Turners syndrome
B. In boys it commences before the testes begin to increase in size.
C. In girls has a peak velocity that coincides with menarche
D. Is considered to be abnormal if it occurs before 8 years in girls.
E. Has a peak velocity which is higher in girls than in boys.

23. Which patient with delayed puberty requires evaluation?

A.13 year old boy who does not experience testicular enlargement.
B.15 years old girl who has no features of pubertal development
C.15 year old girl with primary amenorrhea who has normal secondary sexual characters.
D.13 year old girl with a 4 month h/o irregular menstrual cycles & normal development of other sexual characters.
E. All of the above

24. Regarding Tamoxifen ,which of the following is correct?

A. Is a pure antagonist of oestrogen receptors.
B. Can cause osteoporosis
C. Is associated with hypokalemia
D. Increases risk of endometrial carcinoma
E. Is antagonist of progesterone receptor.

25. Injections of glucocorticoid is associated with which of the following?

A. Membrane stability in lysosomes & mast cells
B. Fibroblastic activity
C. Anabolic activity in muscle
D. Increase in lymph gland size.
E. None of the above

26. Which statement regarding Vit D is not right?

A. Is essential for normal calcification of bones in children
B. Deficiency may lead to hyperparathyroidism
C. Increases intestinal absorption of calcium
D. Cannot be synthesised in the body.
E. Has to be modified in liver for activation.

27. Risk of tetany is increased due to

A. Onset of respiratory failure
B. Surgical removal of anterior pituitary
C. Sudden increase in plasma magnesium
D. Sudden increase in plasma bicarbonate
E. Onset of renal failure.

28. Insulin secretion is stimulated by

A. Somatostatin
B. Propranolol
C. Noradrenaline
D. Glibenclamide
E. Bendroflumethiazide

29. Surgical removal of Pituitary gland results in increase of

A. Menstrual frequency
B. Axillary hair
C. Plasma osmolality
D. Breast size
E. Sexual desire

30. All of the following in childhood, leads to short stature in adults except

A. Premature puberty
B. Thyroid deficiency
C. Adrenal deficiency
D. Chronic malnutrition
E. Castration

31. Therapy with metformin is associated with

A. Release of insulin from Beta cells of pancreas
B. Therapy is associated with Lactic acidosis
C. Causes hypoglycaemia
D. Reduces prolactin concentration in PCOS
E. None of the above

32. Which statement regarding DKA is not true?

A. Amylase levels may be raised in absence of pancreatitis
B. Normal plasma K+ level does not exclude significant K+ deficiency
C. Plasma glucose may be low
D. Urinary dipstick for ketones may be negative
E. leucocytosis is common & does not confirm infection.

33. Hypoglycemic attacks are not a feature of

A. Galactosemia
B. Fructosemia
C. G-6-PD deficiency
D. Gauchers disease
E. Von Glerkes disease

34. What is the chemical structure of GnRH?

A. Glycoprotein
B. Tripeptide
C. Nonapeptide
D. Octapeptide
E. Decapeptide

35. Which of the following hormones increases the excretion of calcium in Kidney?

A. Insulin
B. Cortisol
C. Calcitonin
D. Parathyroid hormone
E. Antidiuretic hormone

36. What is the chemical structure of Renin?

A. Polypeptide
B. Oligopeptide
C. Glycoprotein
D. Steroid

37. What inhibit glucagon release?

A. Adrenaline
B. Exercise
C. Hypoglycemia
D. Increased amino acids
E. Increased fatty acids

38. Which substance is indicated by letter ‘X’ in the diagram below? (MAR 2017)

A. Cholesterol
B. Testosterone
C. Dihydrotestosterone
D. Androstenedione
E. Aldosterone

39. The Progesterone receptor is example of which type of receptor?

A. Guanylate cyclase receptor
B. Nuclear transcription factor
C. Tyrosine kinase nuclear receptor
D. Ligand-gated ion channel in the cell membrane
E. G protein coupled receptor on the Golgi complex

40. No of carbons in Estrogen? (NEW-previous ask about Androgen)

A. 18
B. 19
C. 20
D. 21
E. 22

41. Iodine accumulation in thyroid cells involves symport with

A. Chloride
B. Potassium
C. Hydrogen
D. Sodium
E. Calcium

42. Gonadotropin Releasing Hormone (GnRH) is what type of Biochemical structure

A. Tripeptide
B. Octapeptide
C. Nanopeptide
D. Decapeptide
E. Polypeptide

43. What is the 2nd common enzymatic deficiency after 21-OH CAH?

A. Desmolase
B. 17-hydroxylase
C. 11-Beta hydroxylase
D. 3Beta-HSD

44. What percentage (T4) is free?

A. 0.1%
B. 1%
C. 5 %
D. 15%
E. 70%

45. Which test you is used to check ovarian reserves in pre-menopausal women

A. Anti-Mullerian hormone
B. FSH
C. LH

46. A male came for infertility check-up who was taking Finasteride. Finasteride exert its action by inhibition of which enzyme?

A. 21-hydroxlase
B. 5-alpha reductase
C. Aromatase
D. Phosphodiesterase
E. Desmolase

47. What is the second common cause of congenital adrenal hyperplasia (CAH)?

A. 17-hydroxylase deficiency
B. 21-hydroxylase deficiency
C. 11-Beta hydroxylase deficiency
D. 3 Beta- hydroxysteroid dehydrogenase deficiency
E. 17 Beta-hydroxysteroid dehydrogenase deficiency

48. Postoperative patient with history of DM and asthma. develops some feeling of unwellness. Sodium 112 mEq/L and other parameters were in normal range. What is the diagnosis?

A. Addison disease
B. Cushing syndrome

49. Which major hormone of pregnancy is produced by the placenta from 16‐hydroxydehydroepiandrosterone sulfate (16‐OH DHEAS)?

A. Estrone
B. Estriol
C. Pregnenolone
D. Dehydroepiandrosterone
E. Estradiol

50. Which of the following hormones stimulate ductal morphogenesis during pregnancy?
(hPL ‐ Human Placental Lactogen
GH ‐ Growth Hormone)

A. Progesterone, Prolactin and hPL
B. Progesterone and hPL
C. Progesterone and GH
D. Oestrogen and GH
E. Oxytocin and hPL

51. What percentage of pregnancies are affected by hypothyroidism (including subclinical hypothyroidism)?

A. <0.5%
B. 1%
C. 2.5%
D. 5%
E. 10%

Endocrinology

Endocrinology

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