Pharmacology Extra Questions

1. Which of the following normal physiological changes seen in pregnancy are associated with a slower drug metabolism?

2. A 17-year-old girl discovers she is pregnant despite taking the oral contraceptive pill. She has recently been prescribed a new medication by her general practitioner. Which of the following drugs is most likely to have interacted with the efficacy of her contraception?

3. Which of the following forms part of phase 2 reactions in drug metabolism?

4. A 23-year-old woman is admitted to hospital as she is acutely unwell, having admitted to taking an overdose. On examination, her temperature is 38.6°C, blood pressure 105/68 mmHg, heart rate 96 beats per minute, and respiratory rate 12 breaths per minute. Her arterial blood gas test shows respiratory alkalosis. What is the most likely drug overdose?

5. A 27-year-old woman attends antenatal clinic at 14 weeks’ gestation. This is her second pregnancy and she suffered a pulmonary embolism during her first pregnancy, 3 years ago. Her thrombophilia screen, taken prior to pregnancy, is negative. What is the most appropriate course of action at this point?

6. Which of the following is a recognised side effect of heparin usage?

7. A 37-year old-woman is requesting analgesia following a caesarean section. You notice that she has von Willebrand disease and wonder how this may affect her coagulation profile.
Which of the following is most likely to represent a patient with von Willebrand disease Prothrombin time Bleeding time Platelet count?

8. A 32-year-old woman suffers a 1500 mL postpartum haemorrhage 15 minutes after delivery. She is given several drugs to contract the uterus and the bleeding stops. One hour later, she is found to have blood pressure of 178/110 mmHg. Which drug is most likely to be responsible for this clinical finding?

9. A 2-year-old child has been investigated by the ear, nose and throat specialists for sensorineural hearing loss. Following a series of investigations he is found to have a defect of the 8th cranial nerve.
Which of the following medications did his mother take during her pregnancy?

10. A 27-year-old woman is treated for severe bronchitis at 38 weeks’ gestation. Her baby, born at 41 weeks’ gestation, has neonatal haemolysis.
Which drug taken by the mother for bronchitis is the cause of the baby’s neonatal haemolysis?

11. A 35-year-old woman, with a history of previous multiple pulmonary embolisms, is now 8 weeks pregnant. Which is the anticoagulant of choice during her pregnancy?

12. A 25-year-old nulliparous woman, with a lifelong history of tonic clonic seizures, sees her neurologist as she wishes to start a family. In addition to her current anticonvulsant therapy which additional drug is now required?

13. A 23-year old woman is 8 weeks pregnant. She has persistent itchy, thick, white vaginal discharge. A high vaginal swab has identified the presence of yeast species. She has already tried topical clotrimazole cream which has provided no relief of her symptoms. Which is the most appropriate treatment for vaginal candidiasis unresponsive to clotrimazole cream?