Pharmacology

1. Atosiban is

A. Progesterone agonist
B. Progesterone antagonist
C. Oxytocin agonist
D. Oxytocin antagonist
E. Uterine stimulant

2. Warfarin acts where in the coagulation cascade?

A. Factor V
B. Factor VII
C. Fibrinogen
D. Prothrombin
E. Vit K antagonist

3. Which of the following is a side effect of Terbutaline?

A. Maternal tachycardia
B. Maternal bradycardia
C. Fetal tachycardia
D. Fetal bradycardia
E. IUGR

4. Which antihypertensive drug used in postpartum period causes postpartum depression ?

A. Methyldopa
B. labetalol
C. Nifedipine
D. lisinopril
E. Hydralazine

5. Mechanism of action of clomiphene citrate is

A. Androgenic steroid
B. Estrogenic steroid
C. Progesterone steroid
D. Gonadotrpohin analogue
E. Selective estrogen receptor modulator

6. Which of the following Antineoplastic drug causes hemorrhagic cystitis?

A. Cisplatin
B. Methotrexate
C. Paclitaxel
D. Cyclophosphamide
E. Vincristine

7. Mechanism of action of Ulipristal acetate

A. Partial progesterone receptor blocker
B. Selective estrogen receptor modulator
C. Prostaglandin analogue
D. Selective progesterone receptor modulator
E. Oxytocin agonist.

8. Which of the following drug causes kernicterus?

A. Penicillin
B. Gentamicin
C. Sulphonamides
D. Methotrexate
E. Erythromycin

9. Second line drug in hyperemesis

A. Chlorpromazine,ondansetron,prochlorpromazine
B. Metoclopramide,prochlorpromazine
C. Metoclopramide,chlorpromazine,ondansetron
D. Ondansetron,prochlorpromazine
E. Metochlopramide,ondansetron

10. Dalteparin a LMWH is measured using

A. APTT
B. PT-INR
C. Anti factor Xa activity

11. Pregnancy rate with COCP if perfectly compliant & non perfectly compliant

A. 0,05 & 2-4
B. 0.1 & 5-6
C. 0.3 & 10-15

12. VTE with cocp

A. 15/100,000
B. 3/100,000
C. 60/100000
D. 3-4/100000

13. Pregnancy with IUCD.what is the risk of ectopic pregnancy?

A. 1/10
B. 1/50
C. 1/20
D. 1/5
E. 1/100

14. When would the efficacy of the combined oral contraceptive pill br reduced?

A. Given together with oral omeprazole for gastritis.
B. Oral rifampicin given for meningitis.
C. Oral sodium valproate for epilepsy
D. Oral tetracycline given for 2 months as treatment for acne.
E. None of the above.

15. Which of the following may reduce the anticoagulant action of warfarin?

A. Oral contraceptive pills
B. Aspirin
C. Diazepam
D. Ranitidine
E. Ciprofloxacin

16. A pregnant woman presents at 8 weeks gestation.she gives H/O pulmonary embolism in the past.which anticoagulant is best suited for her?

A. Aspirin 75 mg
B. Aspirin 300 mg
C. LMWH
D. Warfarin
E. Unfractionated heparin

17. Regarding drug treatment in pregnancy ,which of the following is right?

A.Thiazide diuretics do not reduce placental perfusion.
B. Folic acid supplementation is not required for the pts taking Phenytoin.
C. Heparin causes CNS damage to the fetus
D. Treatment with isotretinoin is a recognised indication for termination of pregnancy.
E. Methyldopa is contraindicated throughout pregnancy.

18. Which drug used in the last 4 weeks of pregnancy is unsafe?

A. Tetracycline
B. Paracetamol
C. Paracetamol
D. Methyldopa
E. None of the above

19. Regarding clomiphene citrate which of the following is correct?

A. Its an antiandrogen
B. Usually started in a dosage of 100 mg.
C. Usually started on D7 of the cycle
D. Associated with visual disturbances
E. Produces direct induction of ovulation.

20. Which of the following is associated with use of methyldopa?

A. Nasal congestion
B. Gingival hypertrophy
C. Cataracts
D. Hirsutism
E. ECG abnormalities

21. Regarding ACE inhibitors which of the following is not correct?

A. May cause fetal death in later pregnancy
B. Impair fetal renal circulation
C. Should be stopped before conception
D. Can be safely used in puerperium
E. Are asso with polyhydramnios.

22. Nalorphine is an antagonist for respiratory depression caused by which of the following?

A. Thiopentone
B. Diazepam
C. Pentazocine
D. Pethidine
E. None of the above

23. Which is an alkylating agent?

A. Cisplatin
B. Methotrexate
C. Doxorubicin
D. Etoposide
E. None of the above

24. Rise in blood sugar level is seen with which of the following

A. Ethanol
B. Thiazide diuretics
C. Gliclazide
D. Atenolol
E. Aspirin

25. Infants of opiate abusing mothers are at a risk of

A. Intrauterine growth restriction
B. Increased metabolic rate
C. Sudden infant death syndrome
D. All of the above
E. None of the above

26. Which of the following is an ACE inhibitor?

A. losartan
B. lisinopril
C. Propranolol
D. Methyldopa
E. Nifedipine

27. Ondensetron mediates its antiemetic action by interacting with which of the following receptors?

A. GABA
B. Dopamine
C. Dopamine
D. Muscarinic/cholinergic
E. Nicotinic/cholinergic

28. Regarding Heparin ,which statement is right?

A. Has no effect on platelet aggregation
B. Induces thrombocytopenia in 20% of patients
C. Enhances antithrombin III activity
D. Readily crosses placenta
E. Not used during breast feeding

29. Which of the following is an effect of metoclopramide?

A. Increases gastric acid secretion
B. Increases gastric fluid pH
C. Acts on central dopaminergic receptors
D. Inhibits upper gastrointestinal motility
E. Decreases gastroesophageal sphincter tone

30. Treatment with glucocorticoids can cause

A. Hypokalemia
B. Hypertrichosis
C. lymphopenia
D. All of the above
E. None of the above

31. Regarding antibiotics,which statement is not right?

A. Streptomycin is nephrotoxic
B. Aminoglycosides are effective against anaerobes
C. Ampicillin may potentiate the anticoagulant effect of warfarin
D. Metronidazole given pre rectal is as effective as given intravenous.
E. Rifampicin use is not associated with an increased risk of neonatal bleeding in the third trimester.

32. Which of the following is true regarding penicillin?

A. Exert action by combining with a transpeptidase
B. Have a spectrum of action ,which is independent of the beta lactam side chain
C. Have significant toxic effects on humans
D. Are not inactivated by the plasmid coded enzymes
E. They are bacteriostatic.

33. Which of the following causes hypothyroidism?

A. Doxycycline
B. Allopurinol
C. Probenecid
D. Amiodarone
E. Diazepam

34. Calcium channel blockers are not used for treating which of the following disease?

A. Angina
B. Hypertension
C. Thyrotoxicosis
D. Pulmonary hypertension
E. Raynauds phenomenon

35. Drugs acting on the uterus,which of the following is not true?

A. Prostaglandin F2alpha may lead to an elevation of blood pressure
B. Ergometrine is an oxytocic
C. Mifepristone is an antiprogestogenic steroid
D. Ergometrine has a greater effect on the uterus at term than in early pregnancy
E. Oxytocin is a nonapeptide hormone.

Pharmacology

Pharmacology

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